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KMID : 0376219860230010181
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Chonnam Medical Journal
1986 Volume.23 No. 1 p.181 ~ p.187
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Effects of Amitriptyline on the Submaxillary Secretion of the Cat
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Abstract
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Tricyclic antidepressants such as amitriptyline and imipramine have been clinically used in treatment of depression, but dry mouth, retention of urine, blurring of vision and constipation were commonly reported as the side-effects following long-term treatment with these drugs. Although all these side-effects have been explained by a parasympatholytic effect of the drugs, detailed mechanism of a parasympatholytic effect of the drugs was not elucidated. Studies on the effect of this drug have been performed mostly on the smooth muscle structures and rarely on the salivary gland. In the present study, the effect of amitriptyilne on the parasympathetically and pilocarpine induced submaxillary secretion and the action mechanism of the drug was explored in ketamine-anesthetized cats. Intravenous amitriptyline decreased the submaxillary secretion evoked by stimulating the chorda tympani in,a dose-dependent manner. A large dose of amitriptyline abolished completely and rapidly the secretion induced either by chorda stimulation or by intramuscular pilocarpine. The inhibitory effect of amitriptyline on the submaxillary secretion was not affected by pretreatment with phenoxybenzamine. These findings suggest that amitriptyline decreases the submaxillary secretion by the parasympatholytic effect which may be due to direct muscarinic receptor blocking action.
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